The Mechanism of Pertussis Cough Revealed by the Mouse-Coughing Model

Author:

Hiramatsu Yukihiro1ORCID,Suzuki Koichiro12,Nishida Takashi1,Onoda Naoki1,Satoh Takashi3,Akira Shizuo34,Ikawa Masahito54,Ikeda Hiroko6,Kamei Junzo7,Derouiche Sandra89,Tominaga Makoto89,Horiguchi Yasuhiko14ORCID

Affiliation:

1. Department of Molecular Bacteriology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan

2. The Research Foundation for Microbial Diseases of Osaka University (BIKEN), Suita, Osaka, Japan

3. Laboratory of Host Defense, World Premier Institute Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan

4. Center for Infectious Disease Education and Research, Osaka University, Suita, Osaka, Japan

5. Department of Experimental Genome Research, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan

6. Department of Pathophysiology and Therapeutics, Hoshi University School of Pharmacy and Pharmaceutical Sciences, Tokyo, Japan

7. Juntendo Advanced Research Institute for Health Science, Juntendo University, Tokyo, Japan

8. Division of Cell Signaling, National Institute for Physiological Sciences, Okazaki, Aichi, Japan

9. Thermal Biology Group, Exploratory Research Center on Life and Living Systems (ExCELLS), Okazaki, Aichi, Japan

Abstract

The Gram-negative bacteriumBordetella pertussiscauses a respiratory disease called whooping cough, or pertussis. This disease is characterized by paroxysmal coughing, the mechanism of which has not been intensively studied because of a lack of versatile animal models that reproduce the cough.

Funder

MEXT | Japan Society for the Promotion of Science

MEXT |Japan Society for the Promotion of Science

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

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