Affiliation:
1. Department of Biochemistry, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
Abstract
Bragg
, P. D. (University of British Columbia, Vancouver, Canada)
and W. J. Polglase
. Action of dihydrostreptomycin and antagonism by cations. J. Bacteriol.
85:
590–594. 1963.—A number of antibiotics including dihydrostreptomycin inhibited the induction of β-galactosidase in
Escherichia coli
and, except in the case of chloramphenicol, magnesium antagonized the inhibition. Of the antibiotics tested, only dihydrostreptomycin caused formation of pyruvate from the oxidation of glucose. Under similar conditions, inhibitors of terminal respiration (cyanide, azide, amobarbital) also caused formation of pyruvate. Magnesium and the polyamines, putrescine and spermidine, were observed to antagonize dihydrostreptomycin in systems in which the antibiotic showed an inhibitory action.
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Cited by
13 articles.
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