Environmental exposure of primary care personnel to ribavirin aerosol when supervising treatment of infants with respiratory syncytial virus infections

Author:

Rodriguez W J1,Bui R H1,Connor J D1,Kim H W1,Brandt C D1,Parrott R H1,Burch B1,Mace J1

Affiliation:

1. Children's Hospital National Medical Center, George Washington University School of Medicine and the Health Sciences, Washington, D.C. 20010.

Abstract

The potential exposure to ribavirin aerosol in the environment was assessed in nurses caring for infants and children with severe lower respiratory tract infections due to respiratory syncytial virus. Ribavirin aerosol was administered via a ventilator, oxygen tent, or oxygen hood. Participants worked directly with infants receiving ribavirin for 20.0 to 35.0 h over a 3-day period. No toxic or adverse effects of ribavirin aerosol were observed in any of the 19 nurses studied, and ribavirin was not detected in erythrocytes, plasma, or urine collected after the potential exposure period.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Reference11 articles.

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2. Catlin D. R. Smith and A. Samuels. 1980. 14C-ribavirin: distribution and pharmacokinetic studies in rats baboons and man p. 83-98. In R. Smith and W. Kirkpatrick (ed.) Ribavirin: a broad spectrum antiviral agent. Academic Press Inc. New York.

3. Connor J. D. M. Hinta and R. Van Dyke. 1984. Ribavarin pharmacokinetics in children and adults during therapeutic trials. In R. A. Smith V. Knight and J. A. Smith (ed.) Clinical applications of ribavirin. Academic Press Inc. New York.

4. Ribavirin: a clinical overview;Fernandez H.;Eur. J. Epidemiol.,1986

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