In Vitro Activities of Tritrpticin Alone and in Combination with Other Antimicrobial Agents against Pseudomonas aeruginosa-Reference-Cited by-同舟云学术

In Vitro Activities of Tritrpticin Alone and in Combination with Other Antimicrobial Agents against Pseudomonas aeruginosa

Published:2006-11 Issue:11 Volume:50 Page:3923-3925
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Cirioni Oscar¹,Giacometti Andrea¹,Silvestri Carmela¹,Della Vittoria Agnese¹,Licci Alberto¹,Riva Alessandra¹,Scalise Giorgio¹

Affiliation:

1. Institute of Infectious Diseases and Public Health, Università Politecnica delle Marche-Ospedali Riuniti Ancona, Ancona, Italy

Abstract

ABSTRACT The in vitro activity of the cathelicidin tritrpticin was investigated against multidrug-resistant Pseudomonas aeruginosa . The isolates were susceptible to the peptide at concentrations of 0.50 to 8 mg/liter. Tritrpticin completely inhibits lipopolysaccharide procoagulant activity at a 10 μM concentration. Fractionary inhibitory concentration indexes (0.385, 0.312, and 0.458) demonstrated synergy between the peptide and β-lactams.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00652-06

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