Influenza Virus NS1 Protein Counteracts PKR-Mediated Inhibition of Replication-Reference-Cited by-同舟云学术

Influenza Virus NS1 Protein Counteracts PKR-Mediated Inhibition of Replication

Published:2000-07 Issue:13 Volume:74 Page:6203-6206
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Bergmann Michael¹,Garcia-Sastre Adolfo²,Carnero Elena²,Pehamberger Hubert³,Wolff Klaus³,Palese Peter²,Muster Thomas³

Affiliation:

1. Department of Surgery1and

2. Department of Microbiology, Mount Sinai Medical Center, New York, New York 100292

3. Department of Dermatology,3University of Vienna Medical School, 1090 Vienna, Austria, and

Abstract

ABSTRACT The availability of an influenza virus NS1 gene knockout virus (delNS1 virus) allowed us to establish the significance of the biological relationship between the influenza virus NS1 protein and double-stranded-RNA-activated protein kinase (PKR) in the life cycle and pathogenicity of influenza virus. Our results show that the lack of functional PKR permits the delNS1 virus to replicate in otherwise nonpermissive hosts, suggesting that the major function of the influenza virus NS1 protein is to counteract or prevent the PKR-mediated antiviral response.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.74.13.6203-6206.2000

Reference37 articles.

1. Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR;Abraham N.;J. Biol. Chem.,1999

2. Cleavage of oligoribonucleotides by the 2′-5′-oligoadenylate-dependent ribonuclease L;Carrol S. S.;J. Biol. Chem.,1996

3. The double-stranded RNA-dependent protein kinase PKR: structure and function;Clemens M. J.;J. Interferon Cytokine Res.,1997

4. Reovirus therapy of tumors with activated ras pathway;Coffey M. C.;Science,1998

5. Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease

Cited by 308 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Host Innate Antiviral Response to Influenza A Virus Infection: From Viral Sensing to Antagonism and Escape;Pathogens;2024-07-03

2. The impact of single-stranded RNAs on the dimerization of double-stranded RNA-dependent protein kinase PKR;Biochemical and Biophysical Research Communications;2024-07

3. Vault RNAs (vtRNAs): Rediscovered non-coding RNAs with diverse physiological and pathological activities;Genes & Diseases;2024-03

4. Impaired influenza A virus replication by the host restriction factor SAMHD1 which inhibited by PA-mediated dephosphorylation of the host transcription factor IRF3;Virology Journal;2024-01-29

5. Influenza Virus Host Restriction Factors: The ISGs and Non-ISGs;Pathogens;2024-01-29