Early Therapy of Vertical Human Immunodeficiency Virus Type 1 (HIV-1) Infection: Control of Viral Replication and Absence of Persistent HIV-1-Specific Immune Responses

Author:

Luzuriaga Katherine12,McManus Margaret12,Catalina Michelle12,Mayack Shane3,Sharkey Mark2,Stevenson Mario2,Sullivan John L.12

Affiliation:

1. Department of Pediatrics1 and

2. Program in Molecular Medicine,2 University of Massachusetts Medical School, Worcester, Massachusetts 01605, and

3. Graduate Program in Immunology/Virology, University of Massachusetts Medical School, Worcester, Massachusetts 016553

Abstract

ABSTRACT Studies of potent antiretroviral combination regimens were undertaken in young infants to evaluate the potential for long-term suppression of viral replication and to evaluate the immune consequences of such therapies. Early combination antiretroviral therapy led to a loss of plasma viremia, cultivable virus, and labile extrachromosomal replication intermediates. Despite preservation of immune function, persistent human immunodeficiency type 1 (HIV-1)-specific immune responses were not detected in most infants. The absence of detectable, persisting immune responses in most HIV-1-infected infants treated early contrasts with what is typically seen in adults who are treated early. These results are consistent with the notion that early combination antiretroviral therapy of HIV-1-infected infants allows the long-term suppression of viral replication.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Reference36 articles.

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