Adenovirus Late Gene Expression Does Not Require a Rev-Like Nuclear RNA Export Pathway-Reference-Cited by-同舟云学术

Adenovirus Late Gene Expression Does Not Require a Rev-Like Nuclear RNA Export Pathway

Published:2000-07-15 Issue:14 Volume:74 Page:6684-6688
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Rabino Claudia¹,Aspegren Anders¹,Corbin-Lickfett Kara²,Bridge Eileen²

Affiliation:

1. Rudbeck Laboratory, Department of Genetics and Pathology, Uppsala University, SE-751 85 Uppsala, Sweden,1 and

2. Department of Microbiology, Miami University, Oxford, Ohio 450562

Abstract

ABSTRACT Adenovirus late mRNA export is facilitated by viral early proteins of 55 and 34 kDa. The 34-kDa protein contains a leucine-rich nuclear export signal (NES) similar to that of the human immunodeficiency virus Rev protein. It was proposed that the 34-kDa protein might facilitate the export of adenovirus late mRNA through a Rev-like NES-mediated export pathway. We have tested the role of NES-mediated RNA export during adenovirus infection, and we find that it is not essential for the expression of adenovirus late genes.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.74.14.6684-6688.2000

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