Dose response of Cryptosporidium parvum in outbred neonatal CD-1 mice-Reference-Cited by-同舟云学术

Dose response of Cryptosporidium parvum in outbred neonatal CD-1 mice

Published:1993-11 Issue:11 Volume:59 Page:3661-3665
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Finch G R¹,Daniels C W¹,Black E K¹,Schaefer F W¹,Belosevic M¹

Affiliation:

1. Department of Civil Engineering, University of Alberta, Edmonton, Canada.

Abstract

Cryptosporidium parvum infectivity in a neonatal CD-1 mouse model was used to determine the dose needed to infect 50% of the population. The 50% infective dose was estimated to be 79 oocysts. It was observed that a mean oral inoculum of 23 oocysts produced infection in 2 of 25 neonatal mice 7 days postinoculation. All animals became infected when the mean oral dose exceeded 310 oocysts per animal. The dose response of C. parvum was modeled with a logit dose-response model suitable for use in water disinfection studies.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/aem.59.11.3661-3665.1993

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