Effect of Fluconazole on the Pharmacokinetics of Doxorubicin in Nonhuman Primates-Reference-Cited by-同舟云学术

Effect of Fluconazole on the Pharmacokinetics of Doxorubicin in Nonhuman Primates

Published:2000-04 Issue:4 Volume:44 Page:1100-1101
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Warren Katherine E.¹,McCully Cynthia M.¹,Walsh Thomas J.¹,Balis Frank M.¹

Affiliation:

1. Pediatric Oncology Branch, National Cancer Institute, Bethesda, Maryland 20892-1928

Abstract

ABSTRACT Antifungal prophylaxis in cancer patients who are undergoing chemotherapy is associated with prolonged neutropenia. We measured the effect of fluconazole on doxorubicin pharmacokinetics in nonhuman primates to determine if neutropenia is related to a pharmacokinetic interaction that delays the clearance of the chemotherapeutic agent. Fluconazole pretreatment had no effect on doxorubicin pharmacokinetics.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.44.4.1100-1101.2000

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