Safety and immunogenicity of Salmonella typhi Ty21a vaccine in young Thai children

Author:

Cryz S J1,Vanprapar N1,Thisyakorn U1,Olanratmanee T1,Losonsky G1,Levine M M1,Chearskul S1

Affiliation:

1. Swiss Serum and Vaccine Institute, Berne.

Abstract

Salmonella typhi Ty21a vaccine in a liquid formulation was evaluated in 634 Thai children 2 to 6 years of age. The seroconversion rate was 69% for those who received vaccine versus 14% for those who received placebo (P < 0.005). The immune responses among vaccine recipients ranged from 60% in 3-year-olds to 81% for 6-year-olds.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Reference17 articles.

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4. Institute of Medicine. 1986. Diseases of importance in developing countries. Appendix D-14. Prospects for immunizing against Salmonella typhi p. 1-10. In New vaccine development: establishing priorities vol. II. National Academy Press Washington D.C.

5. Multiresistant Salmonella typhi in India;Jesudasan M. V.;Lancet,1990

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