Decay Kinetics of Human Immunodeficiency Virus-Specific Effector Cytotoxic T Lymphocytes after Combination Antiretroviral Therapy-Reference-Cited by-同舟云学术

Decay Kinetics of Human Immunodeficiency Virus-Specific Effector Cytotoxic T Lymphocytes after Combination Antiretroviral Therapy

Published:1999-01 Issue:1 Volume:73 Page:797-800
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Ogg G. S.¹,Jin X.²,Bonhoeffer S.²,Moss P.¹,Nowak M. A.³,Monard S.²,Segal J. P.²,Cao Y.²,Rowland-Jones S. L.¹,Hurley A.²,Markowitz M.²,Ho D. D.²,McMichael A. J.¹,Nixon D. F.²

Affiliation:

1. Institute of Molecular Medicine, Nuffield Department of Medicine, Oxford OX3 9DS1; and

2. Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 100162

3. Institute for Advanced Study, Princeton, New Jersey 085403, United Kingdom, and

Abstract

ABSTRACT Little is known of the changes in human immunodeficiency virus type 1 (HIV-1)-specific effector cytotoxic T lymphocytes (CTL) after potent antiretroviral therapy. Using HLA/peptide tetrameric complexes, we show that after starting treatment, there are early rapid fluctuations in the HIV-1-specific CTL response which last 1 to 2 weeks. These fluctuations are followed by an exponential decay (median half-life, 45 days) of HIV-1-specific CTL which continues while viremia remains undetectable. These data have implications for the immunological control of drug-resistant virus.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.73.1.797-800.1999

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