Quasispecies of TT Virus (TTV) with Sequence Divergence in Hypervariable Regions of the Capsid Protein in Chronic TTV Infection-Reference-Cited by-同舟云学术

Quasispecies of TT Virus (TTV) with Sequence Divergence in Hypervariable Regions of the Capsid Protein in Chronic TTV Infection

Published:1999-11 Issue:11 Volume:73 Page:9604-9608
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Nishizawa Tsutomu¹,Okamoto Hiroaki¹,Tsuda Fumio²,Aikawa Tatsuya³,Sugai Yoshiki⁴,Konishi Keiko⁵,Akahane Yoshihiro⁶,Ukita Masato¹,Tanaka Takeshi⁷,Miyakawa Yuzo⁸,Mayumi Makoto¹

Affiliation:

1. Immunology Division and Division of Molecular Virology, Jichi Medical School, Tochigi-Ken 329-0498,1

2. Department of Medical Sciences, Toshiba General Hospital, Tokyo 140-8522,2

3. Aikawa Internal Hospital, Ibaraki-Ken 310-0851,3

4. Department of Internal Medicine, Iwaki Kyoritsu General Hospital, Fukushima-Ken 973-8402,4

5. Department of Clinical Pathology, Kanazawa National Hospital, Ishikawa-Ken 920-0935,5

6. First Department of Internal Medicine, Yamanashi Medical University, Yamanashi-Ken 409-3898,6

7. Japanese Red Cross Saitama Blood Center, Saitama-Ken 338-0001,7 and

8. Miyakawa Memorial Research Foundation, Tokyo 107-0062,8 Japan

Abstract

ABSTRACT Three hypervariable regions were identified in a central portion of open reading frame 1 of TT virus DNA, which codes for a putative capsid protein of 770 amino acids. TT virus circulates as quasispecies, with many amino acid substitutions in hypervariable regions, to evade immune surveillance of the hosts and to establish a persistent infection.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.73.11.9604-9608.1999

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