Minimal Incidence of Serum Antibodies Reactive with Intact Primary Isolate Virions in Human Immunodeficiency Virus Type 1-Infected Individuals-Reference-Cited by-同舟云学术

Minimal Incidence of Serum Antibodies Reactive with Intact Primary Isolate Virions in Human Immunodeficiency Virus Type 1-Infected Individuals

Published:1999-11 Issue:11 Volume:73 Page:9638-9641
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Cavacini Lisa A.¹,Peterson J. Elaine¹,Nappi Erica¹,Duval Mark¹,Goldstein Robert²,Mayer Kenneth²³,Posner Marshall R.¹

Affiliation:

1. Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School,1 and

2. Fenway Community Health Center,2 Boston, Massachusetts, and

3. Department of Medicine and Division of Infectious Diseases, Brown University School of Medicine, Pawtucket Memorial Hospital, Pawtucket, Rhode Island3

Abstract

ABSTRACT Immunoglobulin G reactive with primary isolate virions was detected in 36% of serum samples from individuals infected with human immunodeficiency virus type 1. Of these individuals, serum samples from only 7% captured significant quantities of virus. Virion-specific antibody correlated with CD4 counts and, of more significance, primary isolate neutralization. Further dissection of this response should lead to the identification of antibodies and antigenic epitopes for vaccine purposes.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.73.11.9638-9641.1999

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