Antigen-Specific Expansion of Cytotoxic T Lymphocytes in Acute Measles Virus Infection-Reference-Cited by-同舟云学术

Antigen-Specific Expansion of Cytotoxic T Lymphocytes in Acute Measles Virus Infection

Published:1999-01 Issue:1 Volume:73 Page:67-71
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Mongkolsapaya Juthathip¹,Jaye Assan²,Callan Margaret F. C.¹,Magnusen Albert F.²,McMichael Andrew J.¹,Whittle Hilton C.²

Affiliation:

1. Molecular Immunology Group, Institute of Molecular Medicine, The John Radcliffe, Headington, Oxford OX3 9DS, United Kingdom,1 and

2. MRC Laboratories, Banjul, Fajara, The Gambia2

Abstract

ABSTRACT Skewing of the T-cell receptor repertoire of CD8 + T cells has been shown in some persistent infections with viruses, such as human immunodeficiency virus, simian immunodeficiency virus, and Epstein-Barr virus. We have demonstrated that similar distortions also occur in nonpersistent measles virus infection. In addition, two of four children immunized with live, attenuated measles virus showed larger and more persistent CD8 + T-cell expansions than their naturally infected counterparts. The expanded lymphocyte populations were monoclonal or oligoclonal and lysed target cells infected with recombinant vaccinia virus expressing measles virus protein. These results demonstrate that the expansions of CD8 + T lymphocytes are antigen driven.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.73.1.67-71.1999

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