Dynamics of Human Immunodeficiency Virus Type 1 Replication in Vertically Infected Infants-Reference-Cited by-同舟云学术

Dynamics of Human Immunodeficiency Virus Type 1 Replication in Vertically Infected Infants

Published:1999-01 Issue:1 Volume:73 Page:362-367
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Luzuriaga Katherine¹,Wu Hulin²,McManus Margaret¹,Britto Paula²,Borkowsky William³,Burchett Sandra⁴,Smith Betsy⁵,Mofenson Lynne⁶,Sullivan John L.¹,

Affiliation:

1. Department of Pediatrics, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester,1 and

2. Statistical and Data Analysis Center, Harvard School of Public Health,2 and

3. Department of Pediatrics, New York University, New York, New York3; and

4. Boston Children’s Hospital,4 Boston, Massachusetts;

5. Division of AIDS, National Institute of Allergy and Infectious Diseases,5 and

6. Pediatric, Adolescent and Maternal AIDS Branch, National Institute of Child Health & Human Development,6 National Institutes of Health, Bethesda, Maryland

Abstract

ABSTRACT Plasma human immunodeficiency virus type 1 (HIV-1) turnover and kinetics were studied in children aged 15 days to 2 years following the initiation of a triple antiretroviral drug regimen consisting of zidovudine, lamivudine, and nevirapine. HIV-1 turnover was at least as rapid as that previously described in adults; turnover rates were more rapid in infants and children aged 3 months to 2 years than in infants less than 3 months of age. These data confirm the central role of HIV-1 replication in the pathogenesis of vertical HIV-1 infection and reinforce the importance of early, potent combination therapies for the long-term control of HIV-1 replication.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.73.1.362-367.1999

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