Evaluation of the Antigenic Relationships among Canine Parvovirus Type 2 Variants-Reference-Cited by-同舟云学术

Evaluation of the Antigenic Relationships among Canine Parvovirus Type 2 Variants

Published:2008-03 Issue:3 Volume:15 Page:534-539
ISSN:1556-6811
Container-title:Clinical and Vaccine Immunology
language:en
Short-container-title:Clin Vaccine Immunol

Author:

Cavalli Alessandra¹,Martella Vito¹,Desario Costantina¹,Camero Michele¹,Bellacicco Anna Lucia¹,De Palo Pasquale¹,Decaro Nicola¹,Elia Gabriella¹,Buonavoglia Canio¹

Affiliation:

1. Department of Animal Health and Well-Being, University of Bari, Valenzano, Bari, Italy

Abstract

ABSTRACT The antigenic relationships among the original canine parvovirus type 2 (CPV-2) and the variants CPV-2a, -2b, and -2c were evaluated. Cross-antigenic evaluation revealed clear differences among the CPV variants, which were more appreciable by serum neutralization (SN) than by hemagglutination inhibition. Antigenic differences were found mostly between the original CPV-2 and the variants, but they were also observed among the variants CPV-2a, -2b, and -2c. The variant CPV-2c exhibited a unique antigenic pattern, since it was poorly recognized by the sera of animals immunized with CPV-2, CPV-2a, and CPV-2b. However, animals immunized with CPV-2c exhibited higher SN titers to CPV-2b than to the homologous virus CPV-2c. The observed antigenic differences might drive selection of CPV strains by generating differential immune pressure in the canine population, which raises concerns about vaccine efficacy.

Publisher

American Society for Microbiology

Subject

Microbiology (medical),Clinical Biochemistry,Immunology,Immunology and Allergy

Link

https://journals.asm.org/doi/pdf/10.1128/CVI.00444-07

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