The Poisoned Well: Enhancing the Predictive Value of Antimicrobial Susceptibility Testing in the Era of Multidrug Resistance-Reference-Cited by-同舟云学术

The Poisoned Well: Enhancing the Predictive Value of Antimicrobial Susceptibility Testing in the Era of Multidrug Resistance

Published:2017-08 Issue:8 Volume:55 Page:2304-2308
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Brennan-Krohn Thea¹²,Smith Kenneth P.¹,Kirby James E.¹

Affiliation:

1. Department of Pathology, Beth Israel Deaconess Medical Center, Boston, Massaschusetts, USA

2. Division of Infectious Diseases, Boston Children's Hospital, Boston, Massaschusetts, USA

Abstract

ABSTRACT Antimicrobial susceptibility testing (AST) is a fundamental mission of the clinical microbiology laboratory. Reference AST methods are based on bacterial growth in antibiotic doubling dilution series, which means that any error in the reference method inherently represents at least a 2-fold difference. We describe the origins of current AST reference methodology, highlight the sources of AST variability, and propose ideas for improving AST predictive power.

Funder

HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.00511-17

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