Analytical Performance Characteristics of a New Transcription-Mediated Amplification Assay for Treponema pallidum-Reference-Cited by-同舟云学术

Analytical Performance Characteristics of a New Transcription-Mediated Amplification Assay for Treponema pallidum

Published:2021-07-19 Issue:8 Volume:59 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Getman Damon¹^ORCID,Lin Mike¹,Barakat Nesreen¹,Skvoretz Rhonda¹,Godornes Charmie²,Swenson Paul³,Nenninger Ashley¹,Golden Matthew R.³²,Lukehart Sheila A.²

Affiliation:

1. Hologic, Inc., San Diego, California, USA

2. Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington School of Medicine, Seattle, Washington, USA

3. Public Health—Seattle and King County, Seattle, Washington, USA

Abstract

This study evaluated the performance characteristics of a new research-use-only transcription-mediated amplification (TMA) assay for the detection of rRNA from Treponema pallidum . Analytical sensitivity determined using dark-field microscopy-quantitated T. pallidum was 1.4 organisms/ml (95% confidence interval [CI], 0.7 to 6.33 organisms/ml).

Funder

Hologic

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.00511-21

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