Anti-HSP70 Autoantibody Formation by B-1 Cells in Toxoplasma gondii -Infected Mice-Reference-Cited by-同舟云学术

Anti-HSP70 Autoantibody Formation by B-1 Cells in Toxoplasma gondii -Infected Mice

Published:2000-09 Issue:9 Volume:68 Page:4893-4899
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Chen Mei¹,Aosai Fumie¹,Mun Hye-Seong¹,Norose Kazumi¹,Hata Hidekazu¹,Yano Akihiko¹

Affiliation:

1. Department of Parasitology, Chiba University School of Medicine, Chuo-ku, Chiba 260-8670, Japan

Abstract

ABSTRACT Formation of anti- Toxoplasma gondii HSP70 (TgHSP70) antibody cross-reactive to mouse HSP70 (mHSP70) was observed in the sera of BALB/c (a resistant strain) and C57BL/6 (B6; a susceptible strain) mice after peroral infection with T. gondii cysts of the Fukaya strain. The levels of anti-mHSP70 immunoglobulin G (IgG) autoantibody production in B6 mice were higher than those in BALB/c mice. The isotype and subclass of IgG of anti-TgHSP70 monoclonal antibodies cross-reactive to mHSP70 were μ and γ3. Anti-mHSP70 autoantibody in T. gondii -infected BALB/c and B6 mice was shown to be produced by the CD5 + subset of B cells (B-1a cells) but not by conventional B cells (B-2 cells). The epitopes recognized by anti-mHSP70 autoantibody were located primarily in the C-terminal fragment of mHSP70.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.68.9.4893-4899.2000

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