Evolutionary Model of Cluster Divergence of the Emergent Marine Pathogen Vibrio vulnificus : From Genotype to Ecotype

Author:

López-Pérez Mario1,Jayakumar Jane M.1,Haro-Moreno Jose M.2,Zaragoza-Solas Asier2,Reddi Geethika1,Rodriguez-Valera Francisco2,Shapiro Orr H.3,Alam Munirul4,Almagro-Moreno Salvador15ORCID

Affiliation:

1. Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida, USA

2. Evolutionary Genomics Group, División de Microbiología, Universidad Miguel Hernández, Alicante, Spain

3. Institute for Postharvest and Food Sciences, Volcani Research Center, Rishon LeZion, Israel

4. Molecular Ecology and Metagenomics Laboratory, International Center for Diarrheal Disease Research, Dhaka, Bangladesh

5. National Center for Integrated Coastal Research, University of Central Florida, Orlando, Florida, USA

Abstract

Vibrio vulnificus is an emergent marine pathogen and is the cause of a deadly septicemia. However, the genetic factors that differentiate its clinical and environmental strains and its several biotypes remain mostly enigmatic. In this work, we investigated the underlying genomic properties and population dynamics of the V. vulnificus species to elucidate the traits that make these strains emerge as a human pathogen. The acquisition of different ecological determinants could have allowed the development of highly divergent clusters with different lifestyles within the same environment. However, we identified strains from both clusters in the mucosa of aquaculture species, indicating that manmade niches are bringing strains from the two clusters together, posing a potential risk of recombination and of emergence of novel variants. We propose a new evolutionary model that provides a perspective that could be broadly applicable to other pathogenic vibrios and facultative bacterial pathogens to pursue strategies to prevent their infections.

Funder

Binational Science Foundation

Spanish Ministerio de Economia, Industria y Competitividad

Burnett School of Biomedical Sciences Startup Funds

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3