Ephrin Receptor A4 is a New Kaposi’s Sarcoma-Associated Herpesvirus Virus Entry Receptor-Reference-Cited by-同舟云学术

Ephrin Receptor A4 is a New Kaposi’s Sarcoma-Associated Herpesvirus Virus Entry Receptor

Published:2019-02-26 Issue:1 Volume:10 Page:
ISSN:2161-2129
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Chen Jia¹,Zhang Xianming²,Schaller Samantha¹,Jardetzky Theodore S.³,Longnecker Richard¹^ORCID

Affiliation:

1. Department of Microbiology and Immunology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

2. Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

3. Department of Structural Biology, Stanford University School of Medicine, Stanford, California, USA

Abstract

The overall entry mechanism for herpesviruses is not completely known, including those for the human gammaherpesviruses Kaposi’s sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV). To fully understand the herpesvirus entry process, functional receptors need to be identified. In the current study, we found that EphA4 can also function for a KSHV entry receptor along with EphA2. Interestingly, we found that EphA4 does not function as an entry receptor for EBV, whereas EphA2 does. The discovery of EphA4 as a KSHV entry receptor has important implications for KSHV pathogenesis in humans, may prove useful in understanding the unique pathogenesis of KSHV infection in humans, and may uncover new potential targets that can be used for the development of novel interventional strategies.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

American Cancer Society

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02892-18

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