Strain-Resolved Dynamics of the Lung Microbiome in Patients with Cystic Fibrosis

Author:

Dmitrijeva Marija12,Kahlert Christian R.34,Feigelman Rounak12,Kleiner Rebekka L.5,Nolte Oliver6,Albrich Werner C.4,Baty Florent5,von Mering Christian12ORCID

Affiliation:

1. Department of Molecular Life Sciences, University of Zurich, Zurich, Switzerland

2. Swiss Institute of Bioinformatics, Zurich, Switzerland

3. Infectious Diseases and Hospital Epidemiology, Children’s Hospital of Eastern Switzerland, St. Gallen, Switzerland

4. Infectious Diseases and Hospital Epidemiology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland

5. Pneumology and Sleep Medicine, Cantonal Hospital St. Gallen, St. Gallen, Switzerland

6. Human Microbiology, Centre for Laboratory Medicine, St. Gallen, Switzerland

Abstract

Cystic fibrosis patients frequently suffer from recurring respiratory infections caused by colonizing pathogenic and commensal bacteria. Although modern therapies can sometimes alleviate respiratory symptoms by ameliorating residual function of the protein responsible for the disorder, management of chronic respiratory infections remains an issue.

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Reference118 articles.

1. Cystic fibrosis

2. Cystic Fibrosis Foundation. 2018. Cystic Fibrosis Foundation patient registry 2017 annual data report. https://www.cff.org/Research/Researcher-Resources/Patient-Registry/2017-Patient-Registry-Annual-Data-Report.pdf. Accessed 23 January 2020.

3. Zolin A Orenti A Naehrlich L van Rens J Fox A Krasnyk M Jung A Mei-Zahav M Cosgriff R Storms V. 2019. ECFSPR annual report 2017. https://www.ecfs.eu/sites/default/files/general-content-images/working-groups/ecfs-patient-registry/ECFSPR_Report2017_v1.3.pdf. Accessed 23 January 2020.

4. Future trends in cystic fibrosis demography in 34 European countries

5. Cystic fibrosis transmembrane conductance regulator modulators

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