Humans Surviving Cholera Develop Antibodies against Vibrio cholerae O-Specific Polysaccharide That Inhibit Pathogen Motility-Reference-Cited by-同舟云学术

Humans Surviving Cholera Develop Antibodies against Vibrio cholerae O-Specific Polysaccharide That Inhibit Pathogen Motility

Published:2020-12-22 Issue:6 Volume:11 Page:
ISSN:2161-2129
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Charles Richelle C.¹²^ORCID,Kelly Meagan¹,Tam Jenny M.¹²,Akter Aklima¹³,Hossain Motaher¹³,Islam Kamrul¹³,Biswas Rajib¹³,Kamruzzaman Mohammad¹³,Chowdhury Fahima³,Khan Ashraful I.³,Leung Daniel T.⁴^ORCID,Weil Ana¹²,LaRocque Regina C.¹²,Bhuiyan Taufiqur Rahman³,Rahman Atiqur³,Mayo-Smith Leslie M.¹,Becker Rachel L.¹,Vyas Jatin M.¹²^ORCID,Faherty Christina S.⁵⁶^ORCID,Nickerson Kourtney P.⁵,Giffen Samantha⁷,Ritter Alaina S.¹²,Waldor Matthew K.⁸⁹¹⁰,Xu Peng¹¹,Kováč Pavol¹¹,Calderwood Stephen B.¹²⁸,Kauffman Robert C.¹²¹³,Wrammert Jens¹²¹³,Qadri Firdausi³,Harris Jason B.¹⁵¹⁴,Ryan Edward T.¹²⁷

Affiliation:

1. Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA

2. Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA

3. International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka, Bangladesh

4. Division of Infectious Diseases, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA

5. Department of Pediatrics, MassGeneral Hospital for Children, Boston, Massachusetts, USA

6. Mucosal Immunology and Biology Research Center, Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital, Boston, Massachusetts, USA

7. Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA

8. Department of Microbiology, Harvard Medical School, Boston, Massachusetts, USA

9. Division of Infectious Diseases, Brigham and Women’s Hospital, Boston, Massachusetts, USA

10. Howard Hughes Medical Institute, Boston, Massachusetts, USA

11. NIDDK, LBC, National Institutes of Health, Bethesda, Maryland, USA

12. Division of Infectious Disease, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA

13. Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, USA

14. Division of Pediatric Global Health, Massachusetts General Hospital, Boston, Massachusetts, USA

Abstract

Cholera is a severe dehydrating illness of humans caused by Vibrio cholerae . V. cholerae is a highly motile bacterium that has a single flagellum covered in lipopolysaccharide (LPS) displaying O-specific polysaccharide (OSP), and V. cholerae motility correlates with its ability to cause disease. The mechanisms of protection against cholera are not well understood; however, since V. cholerae is a noninvasive intestinal pathogen, it is likely that antibodies that bind the pathogen or its products in the intestinal lumen contribute to protection from infection. Here, we demonstrate that OSP-specific antibodies isolated from humans surviving cholera in Bangladesh inhibit V. cholerae motility and are associated with protection against challenge in a motility-dependent manner.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | Fogarty International Center

Robert Wood Johnson Foundation Center for Health Policy

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.02847-20

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