The AcrAB-TolC Efflux Pump Impacts Persistence and Resistance Development in Stationary-Phase Escherichia coli following Delafloxacin Treatment-Reference-Cited by-同舟云学术

The AcrAB-TolC Efflux Pump Impacts Persistence and Resistance Development in Stationary-Phase Escherichia coli following Delafloxacin Treatment

Published:2021-07-16 Issue:8 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Byrd Brandon A.¹²,Zenick Blesing¹,Rocha-Granados Maria C.¹,Englander Hanna E.³,Hare Patricia J.¹⁴^ORCID,LaGree Travis J.¹,DeMarco Angela M.¹,Mok Wendy W. K.¹^ORCID

Affiliation:

1. Department of Molecular Biology & Biophysics, UCONN Health, Farmington, Connecticut, USA

2. School of Medicine, University of Connecticut, Farmington, Connecticut, USA

3. Department of Physiology & Neurobiology, University of Connecticut, Storrs, Connecticut, USA

4. School of Dental Medicine, University of Connecticut, Farmington, Connecticut, USA

Abstract

Bacteria have a repertoire of strategies to overcome antibiotics in clinical use, complicating our ability to treat and cure infectious diseases. In addition to evolving resistance, bacteria within genetically clonal cultures can undergo transient phenotypic changes and tolerate high doses of antibiotics.

Funder

Charles H. Hood Foundation

University of Connecticut

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00281-21

Reference62 articles.

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