Nikkomycin Z against Disseminated Coccidioidomycosis in a Murine Model of Sustained-Release Dosing-Reference-Cited by-同舟云学术

Nikkomycin Z against Disseminated Coccidioidomycosis in a Murine Model of Sustained-Release Dosing

Published:2021-09-17 Issue:10 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Sass Gabriele¹^ORCID,Larwood David J.¹²^ORCID,Martinez Marife¹,Chatterjee Paulami¹,Xavier Melissa O.¹³,Stevens David A.¹⁴

Affiliation:

1. California Institute for Medical Research, San Jose, California, USA

2. Valley Fever Solutions, Tucson, Arizona, USA

3. Universidade Federal do Rio Grande, Rio Grande, Brazil

4. Division of Infectious Diseases and Geographic Medicine, Stanford University Medical School, Stanford, California, USA

Abstract

Nikkomycin Z (nikZ) is a chitin synthase inhibitor. Efficacy against Coccidioides has been demonstrated in animal models of pulmonary or brain infection.

Funder

Valley Fever Americas Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00285-21

Reference24 articles.

1. Fiedler HP, Schuz T, Decker H. 1993. Chapter 24. An overview of nikkomycins: history, biochemistry, and applications. In Rippon JW, Fromtling RA (ed), Cutaneous antifungal agents. Marcel Dekker, Inc., New York, NY.

2. Modeling Nikkomycin Z Dosing and Pharmacology in Murine Pulmonary Coccidioidomycosis Preparatory to Phase 2 Clinical Trials

3. Evaluation of nikkomycins X and Z in murine models of coccidioidomycosis, histoplasmosis, and blastomycosis

4. Efficacy of nikkomycin Z against experimental pulmonary blastomycosis

5. Nikkomycin Z—Ready to Meet the Promise?

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