Carbapenem Resistance Determinants Acquired through Novel Chromosomal Integrations in Extensively Drug-Resistant Pseudomonas aeruginosa-Reference-Cited by-同舟云学术

Carbapenem Resistance Determinants Acquired through Novel Chromosomal Integrations in Extensively Drug-Resistant Pseudomonas aeruginosa

Published:2021-06-17 Issue:7 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Janice Jessin¹²^ORCID,Agyepong Nicholas³,Owusu-Ofori Alex⁴,Govinden Usha³,Essack Sabiha Yusuf³,Samuelsen Ørjan¹⁵^ORCID,Sundsfjord Arnfinn¹²,Pedersen Torunn¹^ORCID

Affiliation:

1. Norwegian National Advisory Unit on Detection of Antimicrobial Resistance, Department of Microbiology and Infection Control, University Hospital of North Norway, Tromsø, Norway

2. Department of Medical Biology, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway

3. Antimicrobial Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban, South Africa

4. Department of Clinical Microbiology, School of Medicine and Dentistry, Kwame University of Science and Technology, Kumasi, Ghana

5. Department of Pharmacy, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway

Abstract

Two novel bla DIM-1 - or bla IMP-1 -containing genomic islands (GIs) were discovered by whole-genome sequence analyses in four extensively drug-resistant (XDR) Pseudomonas aeruginosa isolates from inpatients at a tertiary hospital in Ghana. The strains were of sequence type 234 (ST234) and formed a phylogenetic clade together with ST111, which is recognized as a global high-risk clone.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00289-21

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