Identification of Estrogen Receptor Modulators as Inhibitors of Flavivirus Infection-Reference-Cited by-同舟云学术

Identification of Estrogen Receptor Modulators as Inhibitors of Flavivirus Infection

Published:2020-07-22 Issue:8 Volume:64 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Eyre Nicholas S.¹²^ORCID,Kirby Emily N.¹²,Anfiteatro Daniel R.¹²,Bracho Gustavo³,Russo Alice G.⁴,White Peter A.⁴^ORCID,Aloia Amanda L.³,Beard Michael R.¹²

Affiliation:

1. Research Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide, Australia

2. Centre for Cancer Biology, SA Pathology, Adelaide, Australia

3. Cell Screen SA, Flinders Centre for Innovation in Cancer, Flinders University, Bedford Park, Australia

4. School of Biotechnology and Biomolecular Sciences, Faculty of Science, The University of New South Wales, Sydney, Australia

Abstract

Flaviviruses such as Zika virus (ZIKV), dengue virus (DENV), and West Nile virus (WNV) are major global pathogens for which safe and effective antiviral therapies are not currently available. To identify antiviral small molecules with well-characterized safety and bioavailability profiles, we screened a library of 2,907 approved drugs and pharmacologically active compounds for inhibitors of ZIKV infection using a high-throughput cell-based immunofluorescence assay. Interestingly, estrogen receptor modulators raloxifene hydrochloride and quinestrol were among 15 compounds that significantly inhibited ZIKV infection in repeat screens.

Funder

National Health and Medical Research Council

Department of Health | National Health and Medical Research Council

Channel 7 Children's Research Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00289-20

Reference52 articles.

1. The global distribution and burden of dengue