Functional Degeneracy in Paracoccus denitrificans Pd1222 Is Coordinated via RamB, Which Links Expression of the Glyoxylate Cycle to Activity of the Ethylmalonyl-CoA Pathway-Reference-Cited by-同舟云学术

Functional Degeneracy in Paracoccus denitrificans Pd1222 Is Coordinated via RamB, Which Links Expression of the Glyoxylate Cycle to Activity of the Ethylmalonyl-CoA Pathway

Published:2023-07-26 Issue:7 Volume:89 Page:
ISSN:0099-2240
Container-title:Applied and Environmental Microbiology
language:en
Short-container-title:Appl Environ Microbiol

Author:

Kremer Katharina¹,Meier Doreen²,Theis Lisa¹,Miller Stephanie³,Rost-Nasshan Aerin³,Naing Yadanar T.³,Zarzycki Jan¹,Paczia Nicole⁴,Serrania Javier²,Blumenkamp Patrick⁵,Goesmann Alexander⁵,Becker Anke⁶²^ORCID,Thanbichler Martin⁶²⁷,Hochberg Georg K. A.²⁸⁹,Carter Michael S.³^ORCID,Erb Tobias J.¹²^ORCID

Affiliation:

1. Department of Biochemistry and Synthetic Metabolism, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany

2. Center for Synthetic Microbiology (SYNMIKRO), Marburg, Germany

3. Department of Biological Sciences, Salisbury University, Maryland, USA

4. Core Facility for Metabolomics and Small Molecule Mass Spectrometry, Max Planck Institute for terrestrial Microbiology, Marburg, Germany

5. Bioinformatics and Systems Biology, Justus Liebig University Giessen, Giessen, Germany

6. Department of Biology, University of Marburg, Marburg, Germany

7. Max Planck Fellow Group Bacterial Cell Biology, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany

8. Department of Chemistry, University of Marburg, Marburg, Germany

9. Evolutionary Biochemistry Group, Max Planck Institute for Terrestrial Microbiology, Marburg, Germany

Abstract

Carbon metabolism provides organisms with energy and building blocks for cellular functions and growth. The tight regulation between degradation and assimilation of carbon substrates is central for optimal growth.

Funder

Bundesministerium für Bildung und Forschung

Max-Planck-Gesellschaft

Deutsche Forschungsgemeinschaft

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

Link

https://journals.asm.org/doi/pdf/10.1128/aem.00238-23

Reference68 articles.

1. Biochemical unity revisited: microbial central carbon metabolism holds new discoveries, multi-tasking pathways, and redundancies with a reason

2. Synthesis of C4-dicarboxylic acids from acetate by a “glyoxylate bypass” of the tricarboxylic acid cycle

3. Synthesis of Cell Constituents from C2-Units by a Modified Tricarboxylic Acid Cycle

4. Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: The ethylmalonyl-CoA pathway

5. Demonstration of the ethylmalonyl-CoA pathway by using 13C metabolomics

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