Molecular Epidemiological Interpretation of the Epidemic of Extensively Drug-Resistant Tuberculosis in South Africa-Reference-Cited by-同舟云学术

Molecular Epidemiological Interpretation of the Epidemic of Extensively Drug-Resistant Tuberculosis in South Africa

Published:2015-11 Issue:11 Volume:53 Page:3650-3653
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Streicher E. M.¹,Sampson S. L.¹,Dheda K.²,Dolby T.³,Simpson J. A.³,Victor T. C.¹,Gey van Pittius N. C.¹,van Helden P. D.¹,Warren R. M.¹

Affiliation:

1. DST/NRF Centre of Excellence for Biomedical Tuberculosis Research/SAMRC Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, South Africa

2. Lung Infection and Immunity Unit, Department of Medicine, University of Cape Town, Cape Town, South Africa

3. National Health Laboratory Service, Cape Town, South Africa

Abstract

ABSTRACT We show that the interpretation of molecular epidemiological data for extensively drug-resistant tuberculosis (XDR-TB) is dependent on the number of different markers used to define transmission. Using spoligotyping, IS6 110 DNA fingerprinting, and DNA sequence data, we show that XDR-TB in South Africa (2006 to 2008) was predominantly driven by the acquisition of second-line drug resistance.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.01414-15

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