Affiliation:
1. Department of Bacteriology II, National Institute of Infectious Diseases, Tokyo, Japan
Abstract
ABSTRACT
We evaluated the
in vitro
activity of fosfomycin against a total of 192 CTX-M β-lactamase-producing
Escherichia coli
strains isolated in 70 Japanese clinical settings. Most of the isolates (96.4%) were found to be susceptible to fosfomycin. On the other hand, some of the resistant isolates were confirmed to harbor the novel transferable fosfomycin resistance determinants named FosA3 and FosC2, which efficaciously inactivate fosfomycin through glutathione
S
-transferase activity.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Reference13 articles.
1. Beharry, Z., and T. Palzkill. 2005. Functional analysis of active site residues of the fosfomycin resistance enzyme FosA from Pseudomonas aeruginosa. J. Biol. Chem.280:17786-17791.
2. Bernat, B. A., L. T. Laughlin, and R. N. Armstrong. 1999. Elucidation of a monovalent cation dependence and characterization of the divalent cation binding site of the fosfomycin resistance protein (FosA). Biochemistry38:7462-7469.
3. Bernat, B. A., L. T. Laughlin, and R. N. Armstrong. 1997. Fosfomycin resistance protein (FosA) is a manganese metalloglutathione transferase related to glyoxalase I and the extradiol dioxygenases. Biochemistry36:3050-3055.
4. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. 2009
5. Endimiani, A., G. Patel, K. M. Hujer, M. Swaminathan, F. Perez, L. B. Rice, M. R. Jacobs, and R. A. Bonomo. 2009. In vitro activity of fosfomycin against blaKPC-containing Klebsiella pneumoniae isolates, including those nonsusceptible to tigecycline and/or colistin. Antimicrob. Agents Chemother.54:526-529.
Cited by
132 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献