Structural and Biochemical Characterization of the Novel CTX-M-151 Extended-Spectrum β-Lactamase and Its Inhibition by Avibactam-Reference-Cited by-同舟云学术

Structural and Biochemical Characterization of the Novel CTX-M-151 Extended-Spectrum β-Lactamase and Its Inhibition by Avibactam

Published:2021-03-18 Issue:4 Volume:65 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Ghiglione Barbara¹²³,Rodríguez María Margarita¹²³,Brunetti Florencia¹²³,Papp-Wallace Krisztina M.⁴⁵⁶⁷^ORCID,Yoshizumi Ayumi⁸,Ishii Yoshikazu⁸,Bonomo Robert A.⁴⁵⁶⁷^ORCID,Gutkind Gabriel¹²³,Klinke Sebastián⁹^ORCID,Power Pablo¹²³^ORCID

Affiliation:

1. Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Microbiología, Inmunología y Biotecnología, Laboratorio de Resistencia Bacteriana, Buenos Aires, Argentina

2. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina

3. Instituto de Investigaciones en Bacteriología y Virología Molecular (IBaViM), Buenos Aires, Argentina

4. Research Service, Louis Stokes Cleveland Department of Veterans Affairs, Cleveland, Ohio, USA

5. Department of Medicine, Case Western Reserve University, Cleveland, Ohio, USA

6. Center for Proteomics and Bioinformatics, Case Western Reserve University, Cleveland, Ohio, USA

7. Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio, USA

8. Department of Microbiology and Infectious Diseases, Toho University, Tokyo, Japan

9. Fundación Instituto Leloir, IIBBA-CONICET, and Plataforma Argentina de Biología Estructural y Metabolómica PLABEM, Buenos Aires, Argentina

Abstract

The diazabicyclooctane (DBO) inhibitor avibactam (AVI) reversibly inactivates most serine β-lactamases, including the CTX-M β-lactamases. Currently, more than 230 unique CTX-M members distributed in five clusters with less than 5% amino acid sequence divergence within each group have been described.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01757-20

Reference57 articles.

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5. Variants of β-Lactamase KPC-2 That Are Resistant to Inhibition by Avibactam

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