CRISPR/Cas9-Constructed Pseudorabies Virus Mutants Reveal the Importance of UL13 in Alphaherpesvirus Escape from Genome Silencing-Reference-Cited by-同舟云学术

CRISPR/Cas9-Constructed Pseudorabies Virus Mutants Reveal the Importance of UL13 in Alphaherpesvirus Escape from Genome Silencing

Published:2021-02-24 Issue:6 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Van Cleemput Jolien¹^ORCID,Koyuncu Orkide O.¹,Laval Kathlyn¹^ORCID,Engel Esteban A.²^ORCID,Enquist Lynn W.¹

Affiliation:

1. Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA

2. Princeton Neuroscience Institute, Princeton University, Princeton, New Jersey, USA

Abstract

Alphaherpesviruses have mastered various strategies to persist in an immunocompetent host, including the induction of latency and reactivation in peripheral nervous system (PNS) ganglia. We recently discovered that the molecular mechanism underlying escape from latency by the alphaherpesvirus pseudorabies virus (PRV) relies on a structural viral tegument protein.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02286-20

Reference46 articles.

1. Herpesviruses: latency and reactivation – viral strategies and host response

2. The 3 facets of regulation of herpes simplex virus gene expression: A critical inquiry

3. HSV-1 AND 2: Pathogenesis and disease