Isolation of a Human Monoclonal Antibody with Strong Neutralizing Activity against Diphtheria Toxin-Reference-Cited by-同舟云学术

Isolation of a Human Monoclonal Antibody with Strong Neutralizing Activity against Diphtheria Toxin

Published:2006-06 Issue:6 Volume:74 Page:3682-3683
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Kakita Mai¹,Takahashi Tsuyoshi²,Komiya Takako³,Iba Yoshitaka⁴,Tsuji Takao²,Kurosawa Yoshikazu⁴,Takahashi Motohide³

Affiliation:

1. Institute for Antibodies Ltd.

2. Department of Microbiology

3. National Institute of Infectious Diseases, Musashimurayama, Tokyo 208-0011, Japan

4. School of Medicine, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470-1192

Abstract

ABSTRACT We isolated a human monoclonal antibody against diphtheria toxin (DT). It bound to fragment B with a binding activity ( K d ) of 3.01 nM. The neutralizing activity assayed by the rabbit skin test was estimated to be 73,600 IU/g. This could be used as a therapeutic drug against DT in place of the traditional equine sera.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.01731-05

Reference14 articles.

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