Transduction of Nondividing Human Macrophages with Gammaretrovirus-Derived Vectors-Reference-Cited by-同舟云学术

Transduction of Nondividing Human Macrophages with Gammaretrovirus-Derived Vectors

Published:2006-02 Issue:3 Volume:80 Page:1152-1159
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Jarrosson-Wuilleme Loraine¹,Goujon Caroline¹,Bernaud Jeanine²,Rigal Dominique²,Darlix Jean-Luc¹,Cimarelli Andrea¹

Affiliation:

1. LaboRetro, INSERM U412, Ecole Normale Supérieure de Lyon, IFR 128 BioSciences Lyon-Gerland

2. Etablissement Transfusion Sanguine, Lyon, France

Abstract

ABSTRACT It is commonly accepted that infection of nondividing cells by gammaretroviruses such as the murine leukemia viruses is inefficient due to their inability to cross the nuclear envelope barrier. Challenging this notion, we now show that human nondividing macrophages display a specific window of susceptibility to transduction with a Friend murine leukemia virus (F-MLV)-derived vector during their differentiation from monocytes. This finding suggests that factors other than the nuclear membrane govern permissiveness to gammaretroviral infection and raises the possibility of using the macrophage tropism of F-MLV in gene therapy.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.80.3.1152-1159.2006

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