Affiliation:
1. Department of Microbiology, College of Veterinary Medicine, University of Tennessee, Knoxville 37996-0845, USA.
Abstract
Herpes simplex virus infection of the scarified dermis results in infection of the nervous system and, subsequently, a cutaneous lesion in the innervated dermatome. We compared the pathogenesis of such zosteriform lesions in mice lacking or severely depleted of CD4+ or CD8+ T cells because of targeted gene disruption. Mice without CD4+ cells showed markedly increased susceptibility, whereas beta 2 microglobulin knockout mice lacking CD8+ T cells were as resistant to challenge as were immunocompetent mice with the same genetic background. Our results demonstrate that CD4+ T cells are of primary importance in the control of herpes simplex virus infections of the skin and nervous system.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
Cited by
95 articles.
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