Monothiol Glutaredoxin Is Essential for Oxidative Stress Protection and Virulence in Pseudomonas aeruginosa

Author:

Saninjuk Kritsakorn1,Romsang Adisak23ORCID,Duang-nkern Jintana1,Wongsaroj Lampet1,Leesukon Panithi4,Dubbs James M.1,Vattanaviboon Paiboon156,Mongkolsuk Skorn1ORCID

Affiliation:

1. Laboratory of Biotechnology, Chulabhorn Research Institute, Bangkok, Thailand

2. Department of Biotechnology, Faculty of Science, Mahidol University, Bangkok, Thailand

3. Center for Emerging Bacterial Infections, Faculty of Science, Mahidol University, Bangkok, Thailand

4. Molecular Medicine Graduate Program, Faculty of Science, Mahidol University, Bangkok, Thailand

5. Center of Excellence on Environmental Health and Toxicology (EHT), the Office of the Permanent Secretary, Ministry of Higher Education, Science, Research and Innovation, Bangkok, Thailand

6. Program in Applied Biological Sciences: Environmental Health, Chulabhorn Graduate Institute, Chulabhorn Royal Academy, Bangkok, Thailand

Abstract

Glutaredoxins (Grxs) are ubiquitous disulfide reductase enzymes. Monothiol Grxs, containing a CXXS motif, play an essential role in iron homeostasis and maturation of [Fe-S] cluster proteins in various organisms.

Funder

Thailand Science Research and Innovation

Ministry of Higher Education, Science, Research and Innovation, Thailand

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

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