Affiliation:
1. Department of Microbiology, Georgetown University Schools of Medicine and Dentistry, Washington, D.C. 20007
Abstract
An R-type virus-like particle (VLP) has been isolated from the medium of BHK-21-F cells by ultracentrifugation and polyethylene glycol precipitation. The R-type VLP contains RNA which sediments at 60 to 70
S
in sucrose density gradients and has a molecular weight of approximately 10
7
, as estimated by gel electrophoresis. The R-type VLP can be labeled with
3
H-uridine in the presence of actinomycin D. On the basis of morphology, site of maturation, and preliminary biochemical characterization, the R-type VLP does not appear to fit into any of the major groups of animal viruses.
Publisher
American Society for Microbiology
Subject
Virology,Insect Science,Immunology,Microbiology
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