Human Cytomegalovirus Interactions with the Basement Membrane Protein Nidogen 1-Reference-Cited by-同舟云学术

Human Cytomegalovirus Interactions with the Basement Membrane Protein Nidogen 1

Published:2021-01-13 Issue:3 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Kuan Man I¹,Jaeger Hannah K.¹,Balemba Onesmo B.¹,O’Dowd John M.¹,Duricka Deborah¹,Hannemann Holger²,Marx Emmerentia¹,Teissier Natacha³,Gabrielli Liliana⁴,Bonasoni Maria Paola⁵,Keithley Elizabeth M.⁶,Fortunato Elizabeth A.¹^ORCID

Affiliation:

1. Department of Biological Sciences and Center for Reproductive Biology, University of Idaho, Moscow, Idaho, USA

2. The Native Antigen Co., Langford Locks, Kidlington, Oxfordshire, United Kingdom

3. Pediatric ENT Department, Robert Debré Hospital, NeuroDiderot, Université de Paris, Paris, France

4. Operative Unit of Clinical Microbiology, St. Orsola Polyclinic, University of Bologna, Bologna, Italy

5. Pathology Unit, Arcispedale Santa Maria Nuova, Azienda USL-IRCCS, Reggio Emilia, Italy

6. Division of Otolaryngology/Head and Neck Surgery, UC San Diego, La Jolla, California, USA

Abstract

We have found that HCMV infection promotes the elimination of the developmentally important basement membrane protein nidogen 1 (NID1) from its host. The virus both decreased transcription and induced degradation of expressed protein.

Funder

HHS | National Institutes of Health

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.01506-20

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