Evaluation of Acute Hematologic and Long-Term Pulmonary Toxicities of Radioimmunotherapy of Cryptococcus neoformans Infection in Murine Models-Reference-Cited by-同舟云学术

Evaluation of Acute Hematologic and Long-Term Pulmonary Toxicities of Radioimmunotherapy of Cryptococcus neoformans Infection in Murine Models

Published:2004-03 Issue:3 Volume:48 Page:1004-1006
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Dadachova E.¹,Bryan R. A.¹,Frenkel A.¹,Zhang T.¹,Apostolidis C.²,Nosanchuk J. S.³,Nosanchuk J. D.⁴,Casadevall A.⁴⁵

Affiliation:

1. Department of Nuclear Medicine

2. Institute for Transuranium Elements, Heidelberg, Germany

3. Vet Biomedical Sciences, Cornell University, Ithaca, New York

4. Department of Medicine

5. Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx

Abstract

ABSTRACT We evaluated acute hematological and long-term pulmonary toxicity of radioimmunotherapy in murine models of Cryptococcus neoformans infection. Activities up to 250 μCi were well tolerated by healthy A/JCr mice for 213 Bi-18B7 and 188 Re-18B7 monoclonal antibodies. In infected mice, doses up to 150 μCi produced only transient toxicity. The lungs of treated mice had no evidence of radiation fibrosis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.48.3.1004-1006.2004

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