Relative Bioavailability of Three Newly Developed Albendazole Formulations: a Randomized Crossover Study with Healthy Volunteers-Reference-Cited by-同舟云学术

Relative Bioavailability of Three Newly Developed Albendazole Formulations: a Randomized Crossover Study with Healthy Volunteers

Published:2004-03 Issue:3 Volume:48 Page:1051-1054
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Rigter I. M.¹,Schipper H. G.²,Koopmans R. P.³,van Kan H. J. M.¹,Frijlink H. W.⁴,Kager P. A.²,Guchelaar H.-J.¹

Affiliation:

1. Department of Clinical Pharmacy

2. Division of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam

3. Department of Internal Medicine

4. Department of Pharmacy, Division of Pharmaceutical Technology, University of Groningen, Groningen, The Netherlands

Abstract

ABSTRACT This study of healthy volunteers shows that the relative bioavailability of albendazole formulations that use arachis oil-polysorbate 80 or hydroxypropyl-β-cyclodextrin as an excipient was enhanced 4.3- and 9.7-fold compared to the results seen with commercial tablets. Administration of macrogol suppositories did not result in measurable plasma concentrations of albendazole sulfoxide.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.48.3.1051-1054.2004

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