Selection during Cefepime Treatment of a New Cephalosporinase Variant with Extended-Spectrum Resistance to Cefepime in an Enterobacter aerogenes Clinical Isolate-Reference-Cited by-同舟云学术

Selection during Cefepime Treatment of a New Cephalosporinase Variant with Extended-Spectrum Resistance to Cefepime in an Enterobacter aerogenes Clinical Isolate

Published:2004-03 Issue:3 Volume:48 Page:1040-1042
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Barnaud G.¹²,Benzerara Y.¹,Gravisse J.²,Raskine L.²,Sanson-Le Pors M. J.²,Labia R.³,Arlet G.¹

Affiliation:

1. Service de Bactériologie, Hôpital Tenon AP-HP

2. Service de Bactériologie-Virologie, Hôpital Lariboisière AP-HP, Paris

3. CNRS-UBO-MNHN, Unité FRE 2125, Quimper, France

Abstract

ABSTRACT Enterobacter aerogenes resistant to cefepime (MIC, 32 μg/ml) was isolated from a patient treated with cefepime for an infection caused by a strain of E. aerogenes overproducing its AmpC β-lactamase (MIC of cefepime, 0.5 μg/ml). The AmpC β-lactamase of the resistant strain had an L-293-P amino acid substitution and a high k cat / K m ratio for cefepime. Both of these modifications were necessary for resistance to cefepime.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.48.3.1040-1042.2004

Reference15 articles.

1. Barnaud, G., R. Labia, L. Raskine, M. J. Sanson-Le Pors, A. Philippon, and G. Arlet. 2001. Extension of resistance to cefepime and cefpirome associated to a six amino acid deletion in the H-10 helix of the cephalosporinase of an Enterobacter cloacae clinical isolate. FEMS Microbiol. Lett.195:185-190.

2. Most Enterobacter aerogenes Strains in France Belong to a Prevalent Clone

3. Prevalence of outer membrane porin alteration in beta-lactam-antibiotic-resistant Enterobacter aerogenes

4. Molecular epidemiology of an outbreak of multidrug-resistant Enterobacter aerogenes infections and in vivo emergence of imipenem resistance

5. Differences in the resistant variants of Enterobacter cloacae selected by extended-spectrum cephalosporins

Cited by 51 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Activity of cefepime, carbapenems and new β-lactam/β-lactamase inhibitor combinations on Enterobacter cloacae complex and Klebsiella aerogenes in Spain (SMART 2016–2022);JAC-Antimicrobial Resistance;2024-05-06

2. Infectious Diseases Society of America 2023 Guidance on the Treatment of Antimicrobial Resistant Gram-Negative Infections;Clinical Infectious Diseases;2023-07-18

3. Management of Highly Resistant Gram-Negative Infections in the Intensive Care Unit in the Era of Novel Antibiotics;Infectious Disease Clinics of North America;2022-12

4. Class C β-Lactamases: Molecular Characteristics;Clinical Microbiology Reviews;2022-09-21

5. Infectious Diseases Society of America Guidance on the Treatment of AmpC β-lactamase-Producing Enterobacterales, Carbapenem-Resistant Acinetobacter baumannii, and Stenotrophomonas maltophilia Infections;Clinical Infectious Diseases;2021-12-05