Affiliation:
1. Department of Microbiology and Immunology, College of Medicine, Downstate Medical Center, State University of New York, Brooklyn, New York 11203
Abstract
Two pathophysiological effects of endotoxin in mice have been shown to be under the major influence of polygenic inheritance. The first, endotoxemia, was measured by LD
50
assays on hybrids and backcross hybrids of the resistant C
3
H/HeJ and the susceptible A/HJe strains. The LD
50
values of the F1 hybrids and the backcross hybrids were intermediate between the respective parental types. The second effect, the intraperitoneal extravascular leukocyte response to small doses of endotoxin, also was found to follow characteristic patterns of polygenic inheritance. As estimated from an analysis of the variance of mice of the F1 and F2 generations, the degree of genetic determination is approximately 54% for the neutrophil response and 82% for the monuclear response.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
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