Affiliation:
1. Departments of Surgery and Microbiology, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45229
Abstract
The effects of
Bacteroides
sp.,
Fusobacterium mortiferum, Bacteroides fragilis
, and
Sphaerophorus necrophorus
on various parameters of blood coagulation in vivo and in vitro were determined and compared to the coagulation effects of
Escherichia coli
and
Salmonella minnesota
, wild type and R595. Intravenous injection of washed cells, culture filtrate, lipopolysaccharide, or lipid A of the anaerobic gram-negative microorganisms into mice resulted in acceleration of coagulation. Lipopolysaccharide and lipid A of the anaerobic microorganisms had no apparent effect on circulating platelets in mice or rabbits and did not cause aggregation of human platelets in vitro. Washed cells, lipopolysaccharide, and lipid A of
Bacteroides
sp. and
F. mortiferum
also significantly accelerated the clotting time of recalcified platelet poor normal human plasma and C6-deficient rabbit plasma. Lipid A, but not lipopolysaccharide, of
E. coli
and washed cells of
S. minnesota
R595 accelerated coagulation by a similar mechanism. These results indicated that
Bacteroides
sp. and
F. mortiferum
can accelerate blood coagulation in vivo and in vitro by a mechanism which does not involve platelets or terminal components of complement.
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Immunology,Microbiology,Parasitology
Reference37 articles.
1. Acute and recurrent thromboembolic disease: a new concept of etiology;Altemeier W. A.;Ann. Surg.,1969
2. The mitogenic effect of lipopolysaccharide on bone marrow derived mouse Iymphocytes. Lipid A as the mitogenic part of the molecule;Anderson J.;J. Exp. Med.,1973
3. Bacteroides infections on a university surgical service;Beazley R. M.;Surg. Gynecol. Obstet.,1972
4. Biggs R. and R. G. MacFarlane. 1962. Human blood coagulation 3rd ed. Charles C Thomas Springfield Ill.
5. Morphology and enumeration of human blood platelets;Brecher G.;J. Appl. Physiol.,1950
Cited by
38 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献