Replacement of Loop II of VP1 of the DA Strain with Loop II of the GDVII Strain of Theiler’s Murine Encephalomyelitis Virus Alters Neurovirulence, Viral Persistence, and Demyelination-Reference-Cited by-同舟云学术

Replacement of Loop II of VP1 of the DA Strain with Loop II of the GDVII Strain of Theiler’s Murine Encephalomyelitis Virus Alters Neurovirulence, Viral Persistence, and Demyelination

Published:1998-09 Issue:9 Volume:72 Page:7557-7562
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Wada Yoshiaki¹,McCright Ingeborg J.¹,Whitby Frank G.²,Tsunoda Ikuo¹,Fujinami Robert S.¹

Affiliation:

1. Department of Neurology and Pathology1 and

2. Department of Biochemistry,2 University of Utah, Salt Lake City, Utah 84132

Abstract

ABSTRACT Theiler’s murine encephalomyelitis viruses, which are murine picornaviruses, can cause central nervous system inflammatory disease. To study the role of loop II in capsid protein VP1, two mutant viruses of strain DA in which DA loop II amino acids were replaced with strain GDVII amino acids were constructed. Infection of mice with the two mutant viruses led to dramatically different patterns of disease.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.72.9.7557-7562.1998

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4. Purification of Theiler's Murine Encephalomyelitis Virus and Analysis of the Structural Virion Polypeptides: Correlation of the Polypeptide Profile with Virulence

5. Theiler's murine encephalomyelitis virus group includes two distinct genetic subgroups that differ pathologically and biologically

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