Progressive Increase in Antimicrobial Resistance among Invasive Isolates of Haemophilus influenzae Obtained from Children Admitted to a Hospital in Kilifi, Kenya, from 1994 to 2002

Author:

Scott J. Anthony G.12,Mwarumba Salim1,Ngetsa Caroline1,Njenga Salome1,Lowe Brett S.1,Slack Mary P. E.3,Berkley James A.1,Mwangi Isaiah1,Maitland Kathryn14,English Mike15,Marsh Kevin12

Affiliation:

1. Wellcome Trust/Kenya Medical Research Institute, Centre for Geographic Medicine Research—Coast, Kilifi, Kenya

2. Nuffield Department of Clinical Medicine

3. Health Protection Agency Haemophilus Reference Unit, WHO Collaborating Centre for Haemophilus influenzae, John Radcliffe Hospital, Headington, Oxford

4. Department of Academic Paediatrics, Imperial College, London, United Kingdom

5. Department of Paediatrics, Oxford University, John Radcliffe Hospital

Abstract

ABSTRACT Etest susceptibilities to amoxicillin, chloramphenicol, and trimethoprim-sulfamethoxazole of 240 invasive isolates of Haemophilus influenzae cultured from children in rural Kenya were 66%, 66%, and 38%, respectively. Resistance increased markedly over 9 years and was concentrated among serotype b isolates. In Africa, the increasing cost of treating resistant infections supports economic arguments for prevention through conjugate H. influenzae type b immunization.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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