The Macrolide Roxithromycin Impairs NADPH Oxidase Activation and Alters Translocation of Its Cytosolic Components to the Neutrophil Membrane In Vitro-Reference-Cited by-同舟云学术

The Macrolide Roxithromycin Impairs NADPH Oxidase Activation and Alters Translocation of Its Cytosolic Components to the Neutrophil Membrane In Vitro

Published:2005-07 Issue:7 Volume:49 Page:2986-2989
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Abdelghaffar Houria¹,Babin-Chevaye Catherine²,Labro Marie-Thérèse²

Affiliation:

1. Université Hassan II, Faculté des Sciences et Techniques Mohammedia, Département de Biologie, Unité de Biotechnologies de l'Environnement et de la Santé, BP 146 Mohammedia, Morocco

2. INSERM U479, CHU Xavier Bichat, Paris, France

Abstract

ABSTRACT We have studied the interference of roxithromycin with NADPH oxidase, the key enzymatic system for oxidant production by human neutrophils. Roxithromycin alters the reconstitution of an active enzyme and impairs the translocation to the outer membrane of the cytosolic components p47-phox and p67-phox. Interestingly, in resting cells roxithromycin directly triggers the translocation of these factors without stimulating the oxidative burst.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.49.7.2986-2989.2005

Reference12 articles.

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4. El Benna, J., J. Hakim, and M. T. Labro. 1992. Inhibition of human neutrophil protein kinase C activity by the antimalarial drug mefloquine. Biochem. Pharmacol.43:527-532.

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