Expression, Extracellular Secretion, and Immunogenicity of the Plasmodium falciparum Sporozoite Surface Protein 2 in Salmonella Vaccine Strains-Reference-Cited by-同舟云学术

Expression, Extracellular Secretion, and Immunogenicity of the Plasmodium falciparum Sporozoite Surface Protein 2 in Salmonella Vaccine Strains

Published:2001-02 Issue:2 Volume:69 Page:1192-1198
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Gómez-Duarte Oscar G.¹,Pasetti Marcela F.¹,Santiago Araceli¹²,Sztein Marcelo B.¹,Hoffman Stephen L.³,Levine Myron M.

Affiliation:

1. Center for Vaccine Development, Department of Medicine, School of Medicine, University of Maryland, Baltimore, Maryland 212011;

2. Instituto de Ciencias Biomédicas, Universidad Autónoma de México, México City, México2; and

3. Malaria Program, Naval Medical Research Center, Rockville, Maryland 208523

Abstract

ABSTRACT Deleting transmembrane α-helix motifs from Plasmodium falciparum sporozoite surface protein (SSP-2) allowed its secretion from Salmonella enterica serovar Typhimurium SL3261 and S. enterica serovar Typhi CVD 908- htrA by the Hly type I secretion system. In mice immunized intranasally, serovar Typhimurium constructs secreting SSP-2 stimulated greater gamma interferon splenocyte responses than did nonsecreting constructs ( P = 0.04).

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.69.2.1192-1198.2001

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