Mechanisms Mediating Porphyromonas gingivalis Gingipain RgpA-Induced Oral Mucosa Inflammation In Vivo-Reference-Cited by-同舟云学术

Mechanisms Mediating Porphyromonas gingivalis Gingipain RgpA-Induced Oral Mucosa Inflammation In Vivo

Published:2001-02 Issue:2 Volume:69 Page:1199-1201
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Rubinstein Israel¹²,Potempa Jan³,Travis James⁴,Gao Xiao-Pei¹

Affiliation:

1. Departments of Medicine1 and

2. Pharmaceutics and Pharmacodynamics,2

3. University of Illinois at Chicago and VA Chicago Health Care System West Side Division, Chicago, Illinois 60612; Department of Microbiology, Institute of Molecular Biology, Tagiellonian University, Krakow, Poland3; and

4. Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 306024

Abstract

ABSTRACT Suffusion of gingipain RgpA (GRgpA) elicited a significant concentration-dependent increase in the clearance of macromolecules from in situ hamster cheek pouch which was attenuated by NPC 17647, a selective bradykinin B 2 receptor antagonist. Leupeptin and a mixture of proteinase inhibitors also attenuated GRgpA-induced responses. These data indicate that GRgpA elicits plasma exudation from in situ oral mucosa in a catalytic site-dependent fashion by elaborating bradykinin.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.69.2.1199-1201.2001

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