A Leucine-Rich Repeat Protein Provides a SHOC2 the RAS Circuit: a Structure-Function Perspective-Reference-Cited by-同舟云学术

A Leucine-Rich Repeat Protein Provides a SHOC2 the RAS Circuit: a Structure-Function Perspective

Published:2021-03-24 Issue:4 Volume:41 Page:
ISSN:0270-7306
Container-title:Molecular and Cellular Biology
language:en
Short-container-title:Mol Cell Biol

Author:

Kwon Jason J.¹²³,Hahn William C.¹²³⁴^ORCID

Affiliation:

1. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA

2. Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA

3. Harvard Medical School, Boston, Massachusetts, USA

4. Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA

Abstract

SHOC2 is a prototypical leucine-rich repeat protein that promotes downstream receptor tyrosine kinase (RTK)/RAS signaling and plays important roles in several cellular and developmental processes. Gain-of-function germ line mutations of SHOC2 drive the RASopathy Noonan-like syndrome, and SHOC2 mediates adaptive resistance to mitogen-activated protein kinase (MAPK) inhibitors.

Funder

Hale Center for Pancreatic Cancer/Dana-Farber Cancer Institute

HHS | NIH | National Cancer Institute

Publisher

American Society for Microbiology

Subject

Cell Biology,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/MCB.00627-20

Reference106 articles.

1. RAS Proteins and Their Regulators in Human Disease

2. Cell Signaling by Receptor Tyrosine Kinases