Beta Interferon Is Produced by Chlamydia trachomatis -Infected Fibroblast-Like Synoviocytes and Inhibits Gamma Interferon-Induced HLA-DR Expression-Reference-Cited by-同舟云学术

Beta Interferon Is Produced by Chlamydia trachomatis -Infected Fibroblast-Like Synoviocytes and Inhibits Gamma Interferon-Induced HLA-DR Expression

Published:1998-09 Issue:9 Volume:66 Page:4491-4495
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Rödel Jürgen¹,Groh Annemarie¹,Vogelsang Heinz²,Lehmann Marc¹,Hartmann Matthias¹,Straube Eberhard¹

Affiliation:

1. Institute of Medical Microbiology1 and

2. Institute of Clinical Immunology,2 Friedrich Schiller University of Jena, D-07743 Jena, Germany

Abstract

ABSTRACT Infection of fibroblast-like synovial cells with Chlamydia trachomatis (serotype D strain IC Cal 8) in culture induced the secretion of beta interferon (IFN-β). Chlamydial infection inhibited IFN-γ-induced expression of HLA-DR antigen in the cells. Addition of IFN-β antibody directly to infected cultures mitigated HLA-DR inhibition, suggesting involvement of produced IFN-β.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.66.9.4491-4495.1998

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5. In situ hybridization for detection of inapparent infection with Chlamydia trachomatis in synovial tissue of a patient with Reiter’s syndrome;Beutler A. M.;Am. J. Med. Sci.,1995

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